President Joe Biden signed an executive order Thursday that hands down sanctions against Israeli settlers in the West Bank who commit acts of violence against Palestinians.

The move, which is a nod to Democrats who have protested against Israel’s actions in its war with Hamas, is the biggest action Biden has taken thus far against Israelis since the conflict began on Oct. 7, 2023.

Sanctions will include blocking settlers who have committed acts of violence from accessing U.S. property or assets, from engaging with the American financial system, and from entering the United States. Similarly, Americans will be barred from contributing money, goods, or services to the sanctioned.

“The situation in the West Bank — in particular high levels of extremist settler violence, forced displacement of people and villages, and property destruction — has reached intolerable levels and constitutes a serious threat to the peace, security, and stability of the West Bank and Gaza, Israel, and the broader Middle East region,” Biden’s executive order reads.

“These actions undermine the foreign policy objectives of the United States, including the viability of a two-state solution and ensuring Israelis and Palestinians can attain equal measures of security, prosperity, and freedom,” it continues.

The moves mirror sanctions imposed on individuals who have been designated as terrorists.

Biden has faced protesters calling for a ceasefire in the conflict for months, including a group that blocked several major streets in Washington on Thursday morning.

The president also mentioned the conflict during his remarks at the National Prayer Breakfast, saying he was praying for “all of those who are living in dire circumstances, innocent men, women, and children held hostage or under bombardment or displaced, not knowing where their next meal will come front, or if it will come at all.”